No correlation between symptom duration and intrathecal production of IgM and/or IgG antibodies in Lyme neuroborreliosis – a retrospective cohort study in Denmark

Ingrid Krogen,Sigurdur Skarphédinsson,Thøger Gorm Jensen,Fredrikke Christie Knudtzen

Journal of Infection（2022）

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摘要

•No association between symptom delay and presence of CSF B.burgdorferi IgM and/or IgG.•Most of LNB patients do not convert from B.burgdorferi IgM to IgG antibodies in CSF.•Type of CSF antibodies associated with different LNB symptom presentations.•B.burgdorferi CSF antibody type cannot be used to interpret stage of disease in LNB.

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关键词

Lyme neuroborreliosis,Borrelia burgdorferi sensu lato,Cerebrospinal fluid,Intrathecal borrelia burgdorferi antibody index

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