Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell Responses.

Ernesto Gargiulo,Elodie Viry,Pablo Elías Morande,Anne Largeot,Susanne Gonder,Feng Xian,Nikolaos Ioannou,Mohaned Benzarti,Felix Bruno Kleine Borgmann,Michel Mittelbronn,Gunnar Dittmar,Petr V Nazarov,Johannes Meiser,Basile Stamatopoulos,Alan G Ramsay,Etienne Moussay,Jérôme Paggetti

Blood cancer discovery（2023）

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摘要

sEVs produced in the leukemia microenvironment impair CD8+ T-cell mediated antitumor immune response and are indispensable for leukemia progression in vivo in murine preclinical models. In addition, high expression of sEV-related genes correlated with poor survival and unfavorable clinical parameters in CLL patients. See related commentary by Zhong and Guo, p. 5. This article is highlighted in the In This Issue feature, p. 1.

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extracellular vesicle secretion,leukemia cells,promotes cll progression,t-cell

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