Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides

Denis Sudarikov, Yulia Gyrdymova,Alexander Borisov,Julia M. Lukiyanova,Roman Rumyantcev,Oksana G. Shevchenko,Diana R. Baidamshina,Nargiza D. Zakarova,Airat R. Kayumov,Ekaterina O. Sinegubova,Alexandrina S. Volobueva,Vladimir V. Zarubaev,Svetlana A. Rubtsova

MOLECULES（2022）

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摘要

New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48–88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73–95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.

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关键词

unsymmetrical,monoterpenylhetaryl disulfides,antioxidant,antibacterial,antifungal activity,cytotoxicity,mutagenicity

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