Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

Clinical Lymphoma Myeloma and Leukemia（2022）

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摘要

•Prolonged, but not intermittent, XPO1 inhibition stably downregulates HOX/MEIS and induces differentiation in NPM1-mutated AML cells.•Prolonged XPO1 inhibition results in remarkable antileukemic activity in vivo in NPM1-mutated leukemic mice.

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xpo1 inhibition,optimal antileukemic activity

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