Poster: AML-144 Uroporphyrinogen Decarboxylase (UROD) Is a Therapeutically Targetable Dependency in Acute Erythroid Leukemia

Jake Friske,Yu Fukuda,Emily Backhaus,Prady Baviskar, Francesca Benini,Jon Connelly,Jonathon Klein,Trevor Cunningham,Jiyang Yu,Shondra Pruett-Miller,John Schuetz,Charles Mullighan,Ilaira Iacobucci

Clinical Lymphoma Myeloma and Leukemia（2022）

引用 0|浏览6

暂无评分

摘要

Through whole-genome CRISPR knockout screening and functional studies, we show that UROD is a dependency in AEL and provides a basis for exploring its therapeutic inhibition.

查看译文

关键词

AML,AEL,UROD,heme synthesis,RNP

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要