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CML-164 Dihydroorotate Dehydrogenase Inhibition Reveals Metabolic Vulnerability in Chronic Myeloid Leukemia

Mohammad Houshmand,Nicoletta Vitale,Francesca Orso,Alessandro Cignetti,Ivan Molineris,Valentina Gaidano,Stefano Sainas,Marta Giorgis,Donatella Boschi,Carmen Fava,Alessandra Iurlo,Elisabetta Abruzzese,Massimo Breccia,Olga Mulas,Giovanni Caocci,Fausto Castagnetti,Daniela Taverna,Fabrizio Pane,Marco Lolli,Paola Circosta

Clinical Lymphoma Myeloma and Leukemia（2022）

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摘要
Our study shows that DHODH inhibition is a promising approach for targeting CML stem/progenitor cells and may help more patients discontinue the therapy. This work was supported by Associazione Italiana per la Ricerca sul Cancro: IG-23344.
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关键词
CML,chronic myeloid leukemia (CML),dihydroorotate dehydrogenase,Meds433
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