Treatment of acquired transthyretin amyloidosis in domino liver transplantation.

Konstantinos I Tsamis,Dimitrios Mytilinaios,Michael Heneghan,Julian D Gillmore,Janet A Gilbertson,Sotirios Giannopoulos,Ioannis Sarmas,Spyridon Konitsiotis

Clinical transplantation（2023）

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摘要

The case presented here supports the concept that patisiran can target the hepatocytes producing the mutated transthyretin in acquired transthyretin amyloidosis, as efficiently as in hereditary transthyretin amyloidosis (hATTR), and can be used to treat patients with transthyretin amyloidosis after DLT.

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关键词

RNA interference,amyloidosis,liver transplant,patisiran,transthyretin

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