Inhibition of the dopamine transporter promotes lysosome biogenesis and ameliorates Alzheimer's disease-like symptoms in mice.

Limin Yin,Jianhui Zhou,Tianyou Li,Xinghua Wang,Wenlong Xue,Jie Zhang,Lingxi Lin,Ning Wang,Xinyi Kang,Yu Zhou,Hong Liu,Yang Li

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

We identified the DAT-CDK9-TFEB signaling axis as a novel regulator of lysosome biogenesis. Our study sheds light on the mechanisms of protein quality control under pathophysiological conditions.

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关键词

Alzheimer's disease,CDK9,TFEB,dopamine transporter,lysosome biogenesis

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