Novel association of SNP rs2297828 in PRDM16 gene with predisposition to type 2 diabetes

Hongmei Zhang,Qiuyue Guan,Ruyi Wang,Shanshan Yang,Xiaoqian Yu,Daxin Cui,Zhiguang Su

Gene（2023）

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摘要

•PRD1-BF-1-RIZ1 homology (PR) domain containing protein-16 (PRDM16) regulates energy homeostasis and glucose and lipid metabolism, which are implicated in the etiology of type 2 diabetes (T2D).•The promoter variant rs2297828 of PRDM16is associated with T2D susceptibility and dyslipidemia.•rs2297828 is a functional variant influencing PRDM16 promoter activity.

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关键词

PR domain containing protein-16,Type 2 diabetes,Genetic association,Promoter activity

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