Lithocholic acid promotes rosacea-like skin inflammation via G protein-coupled bile acid receptor 1

Wenqin Xiao,Mengting Chen, Qinqin Peng,Ke Sha, Tangxiele Liu,Jialin Xia, Hongfu Xie,Ji Li, San Xu,Zhili Deng

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease（2022）

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摘要

•Bile acid profile is varied in the peripheral blood circulation of rosacea patients.•Lithocholic acid promotes rosacea through transmembrane G protein-coupled bile acid receptor 1.•LCA induces inflammatory cytokines and chemokines via G protein-coupled bile acid receptor 1.

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关键词

rosacea,Lithocholic acid,Bile acid,TGR5,Inflammation

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