The role of botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury.

Huilian Bu,Pengfei Jiao,Xiaochong Fan, Yan Gao,Lirong Zhang,Haiming Guo

The Korean journal of pain（2022）

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摘要

BTX-A regulated the levels of CXCL13/CXCR5 and GAT-1 in the spine and DRG through axonal transport. Chemokines (such as CXCL13) may be transported from the injury site to the spine or DRG through axonal transport. Axon molecular transport may be a target to enhance pain management in neuropathic pain.

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关键词

Axonal Transport,Botulinum Toxins,Chemokine,Chemokines,Colchicine,GABA Plasma Membrane Transport Proteins,Hyperalgesia,Neuralgia,Receptors,Sciatic Nerve.,Type A

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