Modeling KLB deficiency by genome editing in hepatocytes: from oxidative stress and inflammation towards enhanced proliferation

Introduction: We previously reported that the rs17618244 G>A variant in the β-Klotho (KLB) gene, encoding the hepatic co-receptor of fibroblast growth factor receptor 4 (FGFR4), dampened KLB plasma levels, leading to inflammation, ballooning and fibrosis both in pediatric and adult patients with nonalcoholic fatty liver disease (NAFLD).