OXIDATIVE STATUS AND STATE OF ERYTHROCYTE MEMBRANES IN PATIENTS WITH CONTROLLED AND TRUE RESISTANT ARTERIAL HYPERTENSION

Today, arterial hypertension is a global health problem in the whole world. The purpose of the study is to assess the oxidative status and the structural condition of erythrocyte membranes in patients with controlled and true resistant arterial hypertension. In patients, a deterioration in the oxidative status in the development of oxidative stress is observed as evidenced by a significant (p<0.05) increase in myeloperoxidase activity, accumulation of lipid and protein oxidation products, decreased antioxidant enzyme activity and reduced glutathione content. Structural and dynamic changes in the membranes of erythrocytes in these patients by the method of spin probes using the nitroxyl radical AdTEMPO and the damage to the structural organization of the lipid layer and proteins integrated in it as well as antioxidant system of erythrocytes were demonstrated. The obtained results may indicate an impairment of the structural organization of the lipid layer and its integrated proteins.