679 Transduction of ferret airway, liver and pancreas following a single dose of adeno-associated virus 1

isolates remained susceptible to meropenem and piperacillin/tazobactam, 71% remained susceptible to ceftazidime and cefepime, and 21% remained susceptible to levofloxacin.Additionally, 50% demonstrated an improvement in antibiotic susceptibility, the most common change was from resistant to sensitive to amikacin.Others demonstrated a change from resistant to sensitive for ceftazidime; resistant to intermediate for gentamicin, levofloxacin, and tobramycin; and intermediate to sensitive for cefepime.Twenty-two percent remained resistant to amikacin, and 14% remained resistant to gentamicin and levofloxacin.Finally, 29% had decreased antibiotic susceptibility; the most common finding was changing from sensitive to resistant for gentamicin, tobramycin, and cefepime.Conclusions: Most P. aeruginosa-colonized adults with CF treated with HEMT had a decrease in colonization rate of P. aeruginosa and improvement in susceptibility to common antibiotic therapy.Larger studies are needed to confirm this potential positive impact on the microbiome of adults with CF receiving HEMT.