ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease.

Circulation（2022）

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摘要

These results reveal that de novo purine synthesis plays an important role in VSMC proliferation in arterial disease. These findings suggest that targeting ATIC is a promising therapeutic approach to combat arterial diseases.

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关键词

ATIC,arterial diseases,atherosclerosis,de novo purine synthesis,proliferation,vascular smooth muscle cells

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