Prediction of Alzheimer's Disease Using Patterns of Methylation Levels in Key Immunologic-Related Genes.

Junhan Lin,Siyu Yang,Chao Wang,Erhan Yu,Zhibao Zhu,Jinying Shi,Xiang Li,Jiawei Xin,Xiaochun Chen,Xiaodong Pan

Journal of Alzheimer's disease : JAD（2022）

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摘要

Our work indicated that methylation levels of 7 key immunologic-related genes (ABCA7, CNR1, CX3CR1, CSF1R, LRRK2, NGFR, and TARDBP) in peripheral blood was altered in AD and the models including methylation of immunologic-related genes biomarkers improved prediction of AD.

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关键词

Alzheimer’s disease,clinical prediction model,immunologic-related genes,methylation,mild cognitive impairment

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