A Novel Case of Chronic Spontaneous Urticaria Associated Chronic Myelogenous Leukemia with Rapid Resolution Upon Treatment with Imatinib

Urticaria is a common reaction of the skin, yet most cases have no identifiable cause. Many etiologies are implicated in causing urticaria such as allergic, physical, autoimmune, vasculitic, psychological, and idiopathic. Formerly known as chronic idiopathic urticaria, chronic spontaneous urticaria (CSU) refers to recurrent urticaria without an identifiable trigger lasting for more than 6 weeks1 Although CSU is most commonly idiopathic, rare cases have suggested it could be a sign of an underlying malignancy.