Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations

Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1 deficiency with invasive M orale and effective treatment options. Mycoplasma orale is a pathobiont that causes rare disease in immunodeficient hosts. Phosphatidylinositol 3-Kinase, Regulatory Subunit 1 (PI3KR1) mutations predisposes patients to infections and autoimmunity and may be a risk factor for M. orale invasive infections