Association of Cyba G640a Variation with Coronary Artery Disease in Indians

Introduction: Oxidative stress induces atherosclerosis by triggering an inflammatory cascade within the vascular wall.Objective: To investigate the role of pro-oxidant and antioxidant gene variations with CAD in Indian subjects.Materials & methods: It's a case-control study and genotyping for the variants MPO G-463A, CYBA G640A, SOD2 Val16Ala and CAT C-262T were performed by conventional PCR techniques.Results: Only CYBA G640A variant allele was found to be significantly (p = 0.0075) associated with CAD.Conclusion: Although CYBA G640A variation was found to be significant, a larger study is needed to validate these results and establish its role as a biomarker.