Apocynin ameliorates fumonisin b1 induced hepatotoxicity via NADPH oxidase inhibition and quantification of sphingosine and sphinganine

•Fumonisin b1 induce hepatotoxicity in mice and reduced the cell viability in HepG2 cells.•Fumonisin b1 disturb sphingolipid metabolism and elevates sphingosine and sphinganine.•Apocynin is NADPH oxidase inhibitor significantly protects the liver damage and showed maximum cell viability.•Apocynin strong antioxidant protects the fumonisin b1 induce oxidative stress and apoptosis via inhibiting NADPH oxidase enzyme.