Phosphorus metabolism in the brain of cognitively normal midlife individuals at risk for Alzheimer's disease

Prodromos Parasoglou,Ricardo S. Osorio,Oleksandr Khegai,Zanetta Kovbasyuk, Margo Miller,Amanda Ho,Seena Dehkharghani,Thomas Wisniewski,Antonio Convit,Lisa Mosconi,Ryan Brown

Neuroimage: Reports（2022）

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摘要

•Local metabolite ratios can be measured with high repeatability (<10% variation).•PCr/α-ATP and Pi/α-ATP are inversely associated with whole brain FDG uptake.•Phosphorus metabolism varies with region and age.

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关键词

Phosphorus magnetic resonance spectroscopy,Brain energy metabolism,Positron emission tomography

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