Comparison of Pain-Like behaviors in two surgical incision animal models in C57BL/6J mice
Neurobiology of Pain(2022)
摘要
•Mechanical hypersensitivity increased in male and female mice for up to 7 seven days after incision surgery in the laparotomy and paw incision models.•Laparotomy surgery but not paw incision reduced several spontaneous behaviors. However this effect dissipated by 24 h post-laparotomy.•Both surgery models increased conditioned place preference for ketoprofen while preference for sucrose was only reduced at 24 h post-laparotomy.
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关键词
Plantar incision,Laparotomy,Spontaneous Behavior,Evoked Behavior,Acute Pain
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