Carbamylation of Integrin α IIb β 3 : The Mechanistic Link to Platelet Dysfunction in ESKD.

Veronika Binder,Barbara Chruścicka-Smaga,Brith Bergum,Stéphane Jaisson,Philippe Gillery,Joar Sivertsen,Tor Hervig,Marta Kaminska,Ronak Tilvawala,Venkatesh V Nemmara,Paul R Thompson,Jan Potempa,Hans-Peter Marti,Piotr Mydel

Journal of the American Society of Nephrology : JASN（2022）

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摘要

Carbamylation of -specifically modification of the K185 residue-might represent a mechanistic link between uremia and dysfunctional primary hemostasis in patients on hemodialysis. The observation that free amino acids prevented the carbamylation-induced loss of activity suggests amino acid administration during dialysis may help to normalize platelet function.

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关键词

carbamylation,chronic hemodialysis,chronic kidney failure,coagulation,end stage renal disease,platelets,protein carbamylation,uremia

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