Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche.

Letter to Blood| January 19, 2023 Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche Motoko Koyama, Motoko Koyama 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Luke Samson, Luke Samson 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Kathleen S. Ensbey, Kathleen S. Ensbey 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Shuichiro Takahashi, Shuichiro Takahashi 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Andrew D. Clouston, Andrew D. Clouston 3Department of Medicine, University of Washington, Seattle, WA Search for other works by this author on: This Site PubMed Google Scholar Paul J. Martin, Paul J. Martin 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA2Envoi Specialist Pathologists, Brisbane, QLD, Australia https://orcid.org/0000-0001-9051-1215 Search for other works by this author on: This Site PubMed Google Scholar Geoffrey R. Hill Geoffrey R. Hill 1Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA2Envoi Specialist Pathologists, Brisbane, QLD, Australia Search for other works by this author on: This Site PubMed Google Scholar Blood (2023) 141 (3): 315–319. https://doi.org/10.1182/blood.2022015808 Article history Submitted: February 4, 2022 Accepted: September 21, 2022 Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Request Permissions Cite Icon Cite Search Site Citation Motoko Koyama, Luke Samson, Kathleen S. Ensbey, Shuichiro Takahashi, Andrew D. Clouston, Paul J. Martin, Geoffrey R. Hill; Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche. Blood 2023; 141 (3): 315–319. doi: https://doi.org/10.1182/blood.2022015808 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBlood Search Subjects: Immunobiology and Immunotherapy, Transplantation TO THE EDITOR: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for the majority of hematological malignancies but is limited by graft-versus-host disease (GVHD) and opportunistic infections. Severe acute GVHD in the gastrointestinal (GI) tract is a major determinant of mortality1 and causes progressive epithelial and crypt loss, leading to denudation of intestinal mucosa.1-3 Approaches to prevent severe GVHD to date focus on the immune suppression of T cells with calcineurin inhibitors, antimetabolites, or alkylating agents.3 Intestinal stem cell (ISC) function and associated intestinal epithelial cell (IEC) renewal are regulated by signaling pathways of WNT, R-spondin, Notch, bone morphogenetic proteins, and epidermal growth factor.4 Stem cell populations expressing leucine-rich repeat-containing G protein−coupled receptor 5 (LGR5) are essential in the renewal of intestinal epithelium during homeostasis. R-spondins are encoded by 4 genes (rspo1, 2, 3, and... References 1.Naymagon S, Naymagon L, Wong SY, et al. Acute graft-versus-host disease of the gut: considerations for the gastroenterologist. 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