Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension.

Petr Kala,Olga Gawrys,Matúš Miklovič,Zdenka Vaňourková,Petra Škaroupková,Šárka Jíchová,Janusz Sadowski,Elzbieta Kompanowska-Jezierska,Agnieszka Walkowska,Josef Veselka,Miloš Táborský,Hana Maxová,Ivana Vaněčková,Luděk Červenka

Journal of hypertension（2023）

引用 8|浏览13

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摘要

The treatment with ET A receptor antagonist delays the onset of decompensation of volume-overload heart failure and improves the survival rate in hypertensive TGR with ACF-induced heart failure. However, the addition of ET A receptor blockade did not enhance the beneficial effects beyond those obtained with standard treatment with ACEi alone.

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关键词

endothelin system,hypertension,Ren-2 renin transgenic rat,renin-angiotensin system,volume-overload heart failure

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