Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimer`s disease modeling mice

Elena Puris,Aaro Jalkanen,Seppo Auriola,Sanna Loppi,Paula Korhonen,Katja M. Kanninen,Tarja Malm,Jari Koistinaho,Mikko Gynther

Brain Disorders（2022）

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摘要

•LPS treatment induced cytosolic PREP protein expression in APdE9 mouse brain cortices.•Cytosolic PREP activity was not altered in brain cortices of LPS-treated APdE9 mice.•Membrane-bound PREP activity decreased in LPS-treated APdE9 mice.•Combination of systemic inflammation and Aβ pathology influences PREP expression.

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关键词

Alzheimer's disease,Prolyl oligopeptidase,Lipopolysaccharide,Amyloid-β,Mouse

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