7. Adoption of optical genome mapping in clinical cancer cytogenetic laboratory: A stepwise approach

Detection of chromosomal abnormalities is important for cancer patients. Compared to common cancer cytogenetics methods including karyotype, fluorescent in-situ hybridization (FISH), and chromosomal microarray (CMA), optical genome mapping (OGM) is an innovative method to detect CA. The objective of this pilot study was to determine a stepwise approach to adopt OGM in the clinical setting. Blinded study was used to compare OGM, karyotype, FISH, and CMA on five well-characterized cancer cases (four leukemia/lymphoma and one solid tumor).