Po-675-07 late sodium channel blocker ranolazine suppresses conduction velocity heterogeneity and spatially discordant alternans and prevent ventricular arrhythmia during therapeutic hypothermia

Chi-Jen Weng,Shang-Ju Wu,Cheng-Hung Li,Jin-Long Huang,Jiunncherng Lin,Yushan Chien,Shien-Fong Lin,Yu-Cheng Hsieh,Shih-Ann Chen

Heart Rhythm（2022）

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摘要

Therapeutic hypothermia (TH) increases the risk of ventricular arrhythmia (VA) by increasing conduction velocity heterogeneity (CVH) and enhancing the spatially discordant alternans (SDA) on action potential duration (APD).

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