PO-705-05 CALCIUM HANDLING ABNORMALITIES CONTRIBUTE TO ARRHYTHMOGENESIS IN DILATED CARDIOMYOPATHY

Dilated cardiomyopathy (DCM) is a major risk factor for heart failure and is associated with the development of life threatening cardiac arrhythmias. It has been shown previously that Ca2+-handling abnormalities may contribute to the pathogenesis of DCM patients harboring a mutation in troponin T (R173W). Whether the altered Ca2+-handling may also contribute to arrhythmogenesis in those patients is currently unknown.