Po-705-08 high-rate pacing suppresses torsade de pointes arrhythmias by reducing spatial dispersion of repolarization

Vera Loen,Valerie van Weperen,Agnieszka Smoczynska,Joanne J.A. van Bavel, Jet D.M. Beekman,Jeanne G. van der Waal,Veronique M.F. Meijborg,Ruben Coronel,Marc A. Vos

Heart Rhythm（2022）

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摘要

An electrical storm of Torsade de Pointes (TdP) arrhythmias can be reproducibly induced in the anesthetized chronic AV-block (CAVB) dog by infusion of the Ikr-blocker dofetilide. Previous studies showed that these arrhythmias arise from a location with high spatial dispersion in repolarization (SDR) and are suppressed by high-rate pacing.

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