CXCL9, CXLC10, and CXCL11 differentially form CXCR3-regulated G protein:beta-arrestin signaling complexes

Chemokine receptors (CKRs) are G protein coupled receptors (GPCRs), a super-family of transmembrane receptors that are the target of ∼1/3 of FDA-approved medications. CKRs are critical regulators of the immune response, in part through their central role in chemotaxis, and therefore play a role in nearly every inflammatory skin condition. Despite their critical role in regulating inflammation, few FDA-approved medications target CKRs. The purpose of this study was to identify CKR signaling pathways that could provide new opportunities for drug development.