Front Cover: Precision Glycodendrimers for DC‐SIGN Targeting (Eur. J. Org. Chem. 29/2022)

The Front Cover shows a blueprint for the design of a multivalent ligand of the C-type lectin receptor DC-SIGN. The compound features a tetravalent rigid scaffold that enables for the multivalent presentation of glycomimetics in a spatially defined fashion. This molecular architecture achieves strong binding avidity towards DC-SIGN and increased selectivity over the C-type lectin langerin, which is characterized by a distinct spatial arrangement of the carbohydrate recognition domains. Cover design by Mr. Francesco Frullini. More information can be found in the Research Article by F. Fieschi, A. Bernardi et al.