The Relative Contribution of High Fat Diet and Hyperglycaemia and Their Combination to the Structural Phenotype of the Diabetic Heart

Type 2 diabetes (T2D) is characterised by chronic hyperglycaemia and results from genetic and lifestyle factors, including high-fat diet (HFD). While both hyperglycaemia and HFD cause remodelling of the heart, it remains unclear which of these, or their combination, contributes to the most severe cardiac phenotype. We aimed to delineate the effects of HFD and hyperglycaemia on pathological pathways of cardiac remodelling.