Endogenous antibody response to SARS-CoV-2 in patients who received monoclonal antibodies against COVID-19: A systematic review

Andrea Lombardi,Cecilia Azzarà,Giulia Renisi,Giulia Viero,Andrea Gori,Alessandra Bandera

Clinical Immunology Communications（2022）

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摘要

Passive immunization with mAbs has been employed in COVID-19. We performed a systematic review of the literature assessing the endogenous humoral immune response against SARS-CoV-2 in patients treated with mAbs. Administration of mAbs in seronegative patients led to a reduction in both antibody titres and neutralizing activity against the virus.

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关键词

Monoclonal antibodies,SARS-CoV-2,Endogenous immune response,Neutralization,Spike protein

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