Role of Ero1α in cognitive impairment induced by chronic hypoxia

Nan Zhang,Yangping Shentu,Min Zhu,Hui Wang,Xianghong Yin,Congkuo Du,Feng Xue,Junming Fan,Yongsheng Gong,Xiaofang Fan

Brain Research（2022）

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摘要

•Ero1α is upregulated under hypoxia condition.•Ero1α upregulation in vivo and in vitro induces neuronal cell apoptosis in hypoxia condition.•Ero1α upregulation in vivo and in vitro may be related to endoplasmic reticulum stress-associated pathways.

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关键词

HIF1α,Ero1α,GRP78,PERK,CHOP,ERS,MWM,FCT,HE,DMSO

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