Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis

Seol Hee Park,Wonhyo Seo,Ming-Jiang Xu,Bryan Mackowiak,Yuhong Lin,Yong He,Yaojie Fu,Seonghwan Hwang,Seung-Jin Kim,Yukun Guan,Dechun Feng,Liqing Yu,Richard Lehner,Suthat Liangpunsakul,Bin Gao

Cellular and Molecular Gastroenterology and Hepatology（2022）

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摘要

Ethanol and its nonoxidative metabolites, FAEEs, not acetaldehyde, promoted acute alcohol-induced liver injury by inducing ER stress, adipocyte death, and lipolysis.

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关键词

Binge,ADH,ALDH,FAEE,Carboxylesterase 1d

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