B–N/B–H Transborylation: Borane-Catalysed Nitrile Hydroboration
Beilstein journal of organic chemistry(2022)
摘要
The reduction of nitriles to primary amines is a useful transformation in organic synthesis, however, it often relies upon stoichiometric reagents or transition-metal catalysis. Herein, a borane-catalysed hydroboration of nitriles to give primary amines is reported. Good yields (48–95%) and chemoselectivity (e.g., ester, nitro, sulfone) were observed. DFT calculations and mechanistic studies support the proposal of a doubleB–N/B–H transborylation mechanism.
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关键词
boron,catalysis,hydroboration,nitrile,transborylation
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