Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity.

Inês C Brás,Mohammad H Khani,Eftychia Vasili,Wiebke Möbius,Dietmar Riedel,Iwan Parfentev,Ellen Gerhardt,Christiane Fahlbusch,Henning Urlaub,Markus Zweckstetter,Tim Gollisch,Tiago F Outeiro

Journal of Parkinson's disease（2022）

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摘要

Overall, our study demonstrates that released proteins can have detrimental effects for surrounding cells, and suggests protein release pathways may be exploited as therapeutic targets in different neurodegenerative diseases.

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关键词

Alpha-synuclein,Tau,extracellular vesicles,huntingtin,neuronal function

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