Involvement of the visfatin/toll-like receptor 4 signaling axis in human dental pulp cell senescence: Protection via toll-like receptor 4 blockade

Chang Youp Ok,Sera Park,Hye-Ock Jang,Moon-Kyoung Bae,Soo-Kyung Bae

Journal of Dental Sciences（2022）

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摘要

Our findings indicate that TLR4 plays an important role in visfatin-induced senescence of hDPCs and suggest that the visfatin/TLR4 signaling axis can be a novel therapeutic target for the treatment of inflammaging-related diseases, including pulpitis.

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关键词

Human dental pulp cells, Inflammaging, Senescence, TLR4, Visfatin

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