Chronic cAMP activation induces adipocyte browning through discordant biphasic remodeling of transcriptome and chromatin accessibility

Jisun So,Solaema Taleb,Jamie Wann,Olivia Strobel,Kyungchan Kim,Hyun Cheol Roh

Molecular Metabolism（2022）

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摘要

•cAMP activation, not PPARγ, induces a biphasic response during adipocyte browning.•Chronic cAMP activation induces discordant transcriptome and chromatin remodeling.•NFIL3 mediates biphasic transition in cAMP-induced adipocyte browning.

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关键词

Beige adipocyte,Transcriptome,Epigenome,NFIL3,Cellular reprogramming,Obesity

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