Study on the mechanism of anti-acute lung injury of Shuanghuanglian oral liquid based on identification of transitional components in blood and network pharmacology

•Identification of transitional components and network pharmacology was combined to explore the anti-ALI mechanism of SHL.•A UHPLC-Q-Exactive Orbitrap-MS method was developed to characterize the metabolic profiling of rat serum after SHL gavage.•Based on network pharmacology, the key anti-acute lung injury targets and pathway of SHL were screened out.