IL-9 stimulates an anti-tumor immune response and facilitates immune checkpoint blockade in the CMT167 mouse model

Yuqian Feng,Sheng Yan,Sze Kwan Lam,Frankie Chi Fat Ko,Caoyang Chen,Mahjabin Khan,James Chung-Man Ho

Lung Cancer（2022）

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摘要

•Study the role of IL-9 in non-small cell lung cancer using CMT167 murine model.•IL-9 increased MHC-I, mediated CD8+ T cells responses and decreased tumor growth.•Synergism of combination of IL-9 and anti-PD-1 in CMT167 lung cancer mouse model.

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关键词

Non-small cell lung cancer,Interleukin-9,MHC-I,Dendritic cells,Immune checkpoint blockade

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