Dynamic contrast enhanced MRI for characterization of blood-brain-barrier dysfunction after traumatic brain injury

Jeffrey B Ware,Saurabh Sinha,Justin Morrison,Alexa E Walter,James J Gugger,Andrea L C Schneider,Cian Dabrowski,Hannah Zamore,Leroy Wesley,Brigid Magdamo,Dmitriy Petrov,Junghoon J Kim,Ramon Diaz-Arrastia,Danielle K Sandsmark

NeuroImage: Clinical（2022）

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摘要

•TBI-related BBB leakage is detectable with DCE-MRI in the early postinjury period.•Subtle BBB permeability elevations are present outside of focal lesions.•BBB disruption is not strongly related to early postinjury symptoms and cognition.•BBB measures exhibit variable changes by 6-month follow-up.

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关键词

TBI,Dynamic contrast-enhanced MRI,Blood–brain-barrier,Microvascular injury

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