Based on 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474), design, synthesis and biological evaluation of novel PI3Kα selective inhibitors

Bioorganic Chemistry（2022）

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摘要

Three series of novel derivatives containing semicarbazones were designed, synthesized and evaluated in this study.

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关键词

PI3-kinase,Semicarbazones,Antitumor,Synthesis,Kinase selectivity

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