Protective effect of obesity on survival in cancers treated with immunotherapy vanishes when controlling for type of cancer, weight loss and reduced skeletal muscle

Sami Antoun,Emilie Lanoy,Samy Ammari,Siham Farhane,Lisa Martin,Caroline Robert,David Planchard,Emilie Routier,Anne Laure Voisin,Sabine Messayke,Stephane Champiat,Jean Marie Michot,Salim Laghouati,Olivier Lambotte,Aurélien Marabelle,Vickie Baracos

European Journal of Cancer（2022）

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摘要

•Association of high BMI with survival is eliminated when adjusted for confounders.•Association of high BMI with survival disappears when adjusted for weight loss.•Weight loss in NSCLC and melanoma is the predominant prognostic factor.•In patients with NSCLC, reduced skeletal muscle is an independent prognostic factor.

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关键词

Obesity paradox,Immune checkpoint inhibitors,Weight loss,Reduced skeletal muscle,Melanoma,Non-small cell lung cancer

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