Stellate cell expression of SPARC-related modular calcium-binding protein 2 is associated with human non-alcoholic fatty liver disease severity.

Frederik T. Larsen,Daniel Hansen,Mike K. Terkelsen,Sofie M. Bendixen,Fabio Avolio,Charlotte W. Wernberg,Mette E.M. Lauridsen,Lea L. Grønkjaer, Birgitte G. Jacobsen,Ellen G. Klinggaard,Susanne Mandrup,Tina Di Caterino,Majken S. Siersbæk,Vineesh Indira Chandran,Jonas H. Graversen,Aleksander A. Krag,Lars Grøntved,Kim Ravnskjaer

JHEP reports : innovation in hepatology（2023）

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摘要

Non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH), are the most common forms of chronic liver diseases. Currently, liver biopsies are the gold standard for diagnosing NAFLD. Blood-based biomarkers to complement liver biopsies for diagnosis of NAFLD are required. We found that activated hepatic stellate cells, a cell type central to NAFLD pathogenesis, upregulate expression of the secreted protein SPARC-related modular calcium-binding protein 2 (SMOC2). SMOC2 was elevated in blood samples from patients with NASH and may hold promise as a blood-based biomarker for the diagnosis of NAFLD.

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关键词

AUROC, area under the receiver operating characteristic curve,ECM, extracellular matrix,HSC, hepatic stellate cells,LSM, liver stiffness measurement,MCP, matricellular protein,NAFL, non-alcoholic fatty liver,NAFLD,NAFLD, non-alcoholic fatty liver disease,NAS, NAFLD activity score,NASH,PCA, principal component analysis,SAF, steatosis, activity, and fibrosis,SE, sensitivity,SMOC2,SMOC2, SPARC-related modular calcium-binding protein 2,SP, specificity,SPARC, secreted protein acidic and cysteine-rich,VSMCs, vascular smooth muscle cells,WGCNA, weighted gene co-expression network analysis,aHSC, activated HSC,hepatic stellate cells,non-invasive biomarker,qHSC, quiescent HSC,smFISH, single-molecule fluorescence in situ hybridisation,transcriptomics

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