Mass photometry reveals SARS-CoV-2 spike stabilisation to impede ACE2 binding through altered conformational dynamics

Chemical Communications（2022）

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摘要

Here we show using mass photometry how proline substitutions, commonly used for SARS-CoV-2 spike stabilisation and vaccine design, directly impedes ACE2 receptor interactions via dynamics of open and closed states....

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关键词

ace2,spike stabilisation,mass photometry,sars-cov

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