Diet restriction-induced mitochondrial signaling and healthy aging

Mitochondrial biogenesis, turnover, and function are metabolically active cellular processes that play crucial roles in regulating organism health and longevity. Mitochondrial metabolism is modulated by dietary interventions such as caloric restriction (CR), the oldest strategy known to promote health span and lifespan effectively, or intermittent fasting, and a plethora of CR mimetics used to emulate its beneficial effects. This chapter will review the mitochondrial pathways induced by dietary restriction regimes, their stimulation by CR mimetics, and their contribution to enhancing resilience to age-associated diseases.