Effects of Repeated Lysergic Acid Diethylamide (LSD) on the Mouse Brain Endocannabinoidome and Gut Microbiome

Antonio Inserra,Giada Giorgini,Sebastien Lacroix,Antonella Bertazzo,Jocelyn Choo, Athanasios Markopolous, Emily Grant,Armita Abolghasemi,Danilo De Gregorio,Nicolas Flamand,Geraint Rogers,Stefano Comai,Cristoforo Silvestri,Gabriella Gobbi,Vincenzo Di Marzo

British Journal of Pharmacology（2022）

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摘要

The prosocial effects elicited by repeated LSD administration are accompanied by alterations of hippocampal eCBome and kynurenine levels, and the composition of the gut microbiota. Modulation of the hippocampal eCBome and kynurenine pathway might represent a mechanism by which psychedelic compounds elicit prosocial effects and affect the gut microbiome.

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关键词

5-hydroxytryptamine system,endocannabinoidome,gut microbiome,kynurenine,lysergic acid diethylamide,repeated,serotonergic system,sociability

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