C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse

Li-Xue Yang,Cheng-Tao Zhang,Meng-Ying Yang,Xue-Hong Zhang,Hong-Chen Liu,Chen-Hui Luo,Yue Jiang,Zhang-Man Wang,Zhong-Yin Yang,Zhao-Peng Shi, Yi-Ci Yang,Ruo-Qu Wei,Li Zhou,Jun Mi,Ai-Wu Zhou,Zhi-Rong Yao,Li Xia,Jin-Song Yan,Ying Lu

Blood（2023）

引用 7|浏览10

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摘要

•C1Q+ cells represent a highly tissue-infiltrative leukemia population and could reconstitute EMI phenotype of AML.•Fibroblast attracts C1Q+ leukemia cell via C1Q–globular C1Q receptor recognition and stimulation of transforming growth factor β1 synthesis.

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关键词

extramedullary infiltration,macrophage-like

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